Recombinant Human CD155/PVR/NECL5 Protein (His Tag)(Active) | PKSH033563

Recombinant Human CD155/PVR/NECL5 Protein (His Tag)(Active) | PKSH033563 | Gentaur US, UK & Europe Disrtribition

Synonyms: Poliovirus Receptor; Nectin-Like Protein 5; NECL-5; CD155; PVR; PVS

Active Protein: Active protein

Activity: Recombinant Human NECL5 is produced by our Mammalian expression system and the target gene encoding Trp21-Asn343(Ile340Met) is expressed with a 6His tag at the C-terminus.

Protein Construction: Recombinant Human NECL5 is produced by our Mammalian expression system and the target gene encoding Trp21-Asn343(Ile340Met) is expressed with a 6His tag at the C-terminus.

Fusion Tag: C-His

Species: Human

Expressed Host: Human Cells

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per μg as determined by the LAL method.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 36.13 kDa

Formulation: Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Reconstitution: Not Applicable

Background: Poliovirus Receptor (PVR) is a 70 kDa type I transmembrane single-span glycoprotein that belongs to the nectin-like (Necl) family and was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV); an etiologic agent of the central nervous system disease poliomyelitis. PVR contains three Ig-like extracellular domains; a transmembrane segment; and a cytoplasmic tail. The normal cellular function of PVR maybe the involvement of intercellular adhension between epithelial cells. Alternate splicing of the PVR mRNA yields four different isoforms (α; β; γ; and δ) with identical extracellular domains.

Research Area: Microbiology