Mouse IL-23 alpha&IL-12 beta Heterodimer Protein, His Tag&Tag Free | ILB-M52W7-1mg

Mouse IL-23 alpha&IL-12 beta Heterodimer Protein, His Tag&Tag Free | ILB-M52W7-1mg| Gentaur Distribution US, UK & Europe

Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Source: Mouse IL-23A&IL-12B Heterodimer Protein, His Tag&Tag Free (ILB-M52W7) is expressed from human 293 cells (HEK293). It contains AA Val 22 - Ala 196 (IL23A) & Met 23 - Ser 335 (IL12B) (Accession # Q9EQ14-1 (IL23A) & P43432-1 (IL12B) ).

Format: Powder.

Tag: N-6×His | Native.

Expression System: HEK293.

Expression Region: Val 22 - Ala 196 (IL23A) & Met 23 - Ser 335 (IL12B).

Conjugate: Unconjugated.

Molecular Weight: 20.5 kDa (IL23A) & 35.8 kDa (IL12B).

Characteristics: Mouse IL-23A&IL-12B Heterodimer Protein, His Tag&Tag Free, produced by co-expression of IL-23A and IL-12B, has a calculated MW of 20.5 kDa (IL-23A) and 35.8 kDa (IL-12B). Subunit IL-23A is fused with a polyhistidine tag at the N-terminus and subunit IL-12B contains no tag. The reducing (R) protein migrates as 19 kDa (IL-23A) and 40-44 kDa (IL-12B) respectively due to glycosylation.

Purity: 90%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT