Human IL-23 alpha&IL-12 beta Heterodimer Protein, His Tag&Tag Free (MALS verified) | ILB-H52W5-1mg

Human IL-23 alpha&IL-12 beta Heterodimer Protein, His Tag&Tag Free (MALS verified) | ILB-H52W5-1mg| Gentaur Distribution US, UK & Europe

Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Source: Human IL-23A&IL-12B Heterodimer Protein, His Tag&Tag Free (ILB-H52W5) is expressed from human 293 cells (HEK293). It contains AA Arg 20 - Pro 189 (IL23A) & Ile 23 - Ser 328 (IL12B) (Accession # Q9NPF7-1 (IL23A) & P29460-1 (IL12B) ).

Format: Powder.

Tag: N-6×His | Native.

Expression System: HEK293.

Expression Region: Arg 20 - Pro 189 (IL23A) & Ile 23 - Ser 328 (IL12B).

Conjugate: Unconjugated.

Molecular Weight: 19.5 kDa (IL23A) & 34.7 kDa (IL12B).

Characteristics: Human IL-23A&IL-12B Heterodimer Protein, His Tag&Tag Free, produced by co-expression of IL-23 alpha and IL-12 beta, has a calculated MW of 19.5 kDa (IL-23 alpha) and 34.7 kDa (IL-12 beta). Subunit IL-23 alpha is fused with a polyhistidine tag at the N-terminus and subunit IL-12 beta contains no tag. The reducing (R) protein migrates as 23 kDa (IL-23 alpha) & 40-45 kDa (IL-12 beta) when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 95%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT