Human IL-23 alpha&Rat IL-12 beta Heterodimer Protein, His Tag&Tag Free (MALS verified) | ILB-HR52W3-1mg

Human IL-23 alpha&Rat IL-12 beta Heterodimer Protein, His Tag&Tag Free (MALS verified) | ILB-HR52W3-1mg| Gentaur Distribution US, UK & Europe

Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Source: Human IL-23A&Rat IL-12B Heterodimer Protein, His Tag&Tag Free (ILB-HR52W3) is expressed from human 293 cells (HEK293). It contains AA Arg 20 - Pro 189 (IL23A) & Met 23 - Ser 335 (IL12B) (Accession # Q9NPF7-1 (IL23A) & Q9R278-1 (IL12B) ).

Format: Powder.

Tag: N-10×His | Native.

Expression System: HEK293.

Expression Region: Arg 20 - Pro 189 (IL23A) & Met 23 - Ser 335 (IL12B).

Conjugate: Unconjugated.

Molecular Weight: 20.6 kDa | 35.9 kDa.

Characteristics: Human IL-23A & Rat IL-12B Heterodimer Protein, His Tag&Tag Free, produced by co-expression of IL-23A and IL-12B, has a calculated MW of 20.6 kDa (IL-23A) and 35.9 kDa (IL-12B). Subunit IL-23A is fused with a polyhistidine tag at the N-terminus and subunit IL-12B contains no tag. The reducing (R) protein migrates as 23 kDa (IL-23A) and 45 kDa and 47 kDa (IL-12B) respectively due to glycosylation.

Purity: 90%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT