Cynomolgus IL-23 alpha&Mouse IL-12 beta Heterodimer Protein, His Tag&Tag Free | ILB-CM52W8-1mg

Cynomolgus IL-23 alpha&Mouse IL-12 beta Heterodimer Protein, His Tag&Tag Free | ILB-CM52W8-1mg| Gentaur Distribution US, UK & Europe

Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Source: Cynomolgus IL-23A&Mouse IL-12B Heterodimer Protein, His Tag&Tag Free (ILB-CM52W8) is expressed from human 293 cells (HEK293). It contains AA Val 22 - Pro 189 (IL23A) & Met 23 - Ser 335 (IL12B) (Accession # A0A2K5TLV4-1 (IL23A) & P43432-1 (IL12B) ).

Format: Powder.

Tag: N-10×His | Native.

Expression System: HEK293.

Expression Region: Val 22 - Pro 189 (IL23A) & Met 23 - Ser 335 (IL12B).

Conjugate: Unconjugated.

Molecular Weight: 20.3 kDa (IL23A) & 35.8 kDa (IL12B).

Characteristics: This protein carries polyhistidine tag at the N-terminus. The protein has a calculated MW of 20.3 kDa (IL23A) & 35.8 kDa (IL12B). The protein migrates as 20-23 kDa (IL23A) & 40-42 kDa and 43-46 kDa (IL12B) when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 90%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT