Foxp3 Reporter (Luc) - Jurkat Recombinant Cell Line | 60628

Foxp3 Reporter (Luc) - Jurkat Recombinant Cell Line | 60628 | Gentaur US, UK & Europe Disrtribition

Category: Immunotherapy/Cell Line

Application: The Foxp3 promoter Jurkat reporter cell line is suitable for monitoring the transcription activity of Foxp3 in response to stimulant, and establishing cell-based screens for inhibitors that target specific Foxp3-stimulating molecules.

Background: Foxp3, belonging to the forkhead family, is a master transcription factor that expresses exclusively in regulatory T cells, a subset of CD4+ T cells. Regulation of Foxp3 is critical for maintaining immunological tolerance. Over-expression of Foxp3 is known to suppress effector T cell activation.

Description: Human Foxp3 luciferase reporter construct is stably integrated into the genome of Jurkat T- cells. The firefly luciferase gene is controlled by a human Foxp3 promoter and an enhancer-like conserved noncoding sequence upstream of the Foxp3 promoter.

Product Type: Cell Line

Shippement Condition: -80°C