TRPC3-HEK293 Cell Line | 90130

TRPC3-HEK293 Cell Line | 90130 | Gentaur US, UK & Europe Disrtribition

Category: Recombinant Cell Line/Ion Channel

Application: • Monitor TRPC3 calcium channel activity
• Screen for activators or inhibitors of TRPC3 calcium channel

Background: TRPC3 channel belongs to the transient receptor potential channel (TRP) superfamily which is divided into seven main subfamilies. TRP channels share a similar architecture of six-transmembrane domains and function as tetramers. Most channels are permeable to calcium and monovalent cations (Vassort et al., 2009). Specifically, TRPC3 channel belongs to a canonical TRP (TRPC) subfamily that is involved in calcium entry. TRPC3 is activated through phospholipase C-linked receptors. When expressed in HEK293 cells, TRPC3 behaves as a receptor activated channel with constitutive activity that cannot be further increased by store depletion (Trebak et al., 2002).

Description: Stable, recombinant HEK293 cell line expressing human TRPC3 (transient receptor potential cation channel, subfamily C, member 3, accession number NM_003305).

Product Type: Cell Line

Shippement Condition: -80°C