TMEM16A-HEK293 Cell Line | 90230

TMEM16A-HEK293 Cell Line | 90230 | Gentaur US, UK & Europe Disrtribition

Category: Recombinant Cell Line/Ion Channel

Application: • Drug compound screening for activators or inhibitors of TMEM16A
• Functional assays for TMEM16A
• Efficient antigen for mouse immunization

Background: Calcium-activated chloride channels (CaCCs) are major regulators in numerous physiological processes including sensory transduction, epithelial secrection, cardiac and neutonal excitation, and smooth muscle contraction. TMEM16A (ANO1), a member of a family of putative plasma membrane proteins, is identified as a CaCC that is activated by intracellular Ca²⁺ and Ca²⁺-mobilizing stimuli. It has eight putative transmembrane segments without domains evidently involved in calcium regulation. The relative permeability of TMEM16A to monovalent anions is NO₃^–> I^–>Br^–> Cl^– > F^–.

Description: Stable, recombinant HEK293 cell line expressing human TMEM16A (transmembrane protein 16A, also called anoctamin 1, calcium-activated chloride channel (ANO1), accession number NM_018043).

Product Type: Cell Line

Shippement Condition: -80°C