Recombinant beta Catenin Monoclonal Antibody | E-AB-81445

Recombinant beta Catenin Monoclonal Antibody | E-AB-81445 | Gentaur US, UK & Europe Disrtribition

Reactivity: Human, Mouse, Rat, Hamster

Host: Rabbit

Isotype: IgG

Application: WB, IHC-P

Research Area: Cancer, Cardiovascular, Neuroscience, Signal Transduction, Stem Cells

Background: CTNNB1, also known as β-Catenin, is an evolutionarily conserved, multifunctional intracellular protein. CTNNB1 was originally identified in cell adherens junctions (Ajs) where it functions to bridge the cytoplasmic domain of cadherins to a-catenin and the actin cytoskeleton. Besides its essential role in the Ajs, CTNNB1 is also a key downstream component of the canonical Wnt pathway that plays diverse and critical roles in embryonic development and adult tissue homeostasis. Deregulation of CTNNB1 activity is associated with multiple diseases including cancers. .

Lead Time: 7~10 days

Concentration: 300 μg/mL

Storage: Store at -20℃. Avoid freeze / thaw cycles.

Immunogen: N/A

Buffer: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Purification: Affinity Purified

Dilution: WB 1:1000-1:2000 IHC 1:50-1:100

Conjugation: Unconjugated

Calculated Molecular Weight: 86kDa

Observed Molecular Weight: 86kDa

Clonality: Rabbit Monoclonal