Catenin beta Monoclonal Antibody | E-AB-70230

Catenin beta Monoclonal Antibody | E-AB-70230 | Gentaur US, UK & Europe Disrtribition

Reactivity: Human, Mouse, Rat

Host: Mouse

Isotype: IgG

Application: WB, IHC

Research Area: Cancer, Cardiovascular, Neuroscience, Signal Transduction, Stem Cells

Background: CTNNB1, also known as β-Catenin, is an evolutionarily conserved, multifunctional intracellular protein. CTNNB1 was originally identified in cell adherens junctions (Ajs) where it functions to bridge the cytoplasmic domain of cadherins to a-catenin and the actin cytoskeleton. Besides its essential role in the Ajs, CTNNB1 is also a key downstream component of the canonical Wnt pathway that plays diverse and critical roles in embryonic development and adult tissue homeostasis. Deregulation of CTNNB1 activity is associated with multiple diseases including cancers. .

Lead Time: 7~10 days

Concentration: 420 μg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant protein corresponding to Mouse β-catenin

Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

Purification: Affinity purification

Dilution: WB 1:500-1:1000, IHC 1:100-1:500

Conjugation: Unconjugated

Calculated Molecular Weight: 92 kDa

Observed Molecular Weight: 92 kDa

Clonality: Monoclonal