(KO Validated) APEX1 Polyclonal Antibody | E-AB-65409

(KO Validated) APEX1 Polyclonal Antibody | E-AB-65409 | Gentaur US, UK & Europe Disrtribition

Reactivity: Human

Host: Rabbit

Isotype: IgG

Application: WB, IF

Research Area: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling

Background: Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.

Lead Time: 7~10 days

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant fusion protein of human APEX1 (NP_542380.1).

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification: Affinity purification

Dilution: WB 1:500-1:2000 IF 1:50-1:100

Conjugation: Unconjugated

Calculated Molecular Weight: 35 kDa

Observed Molecular Weight: 39 kDa

Clonality: N/A