Human CTLA-4 coupled Magnetic Beads | MBS-K042-10mg

Human CTLA-4 coupled Magnetic Beads | MBS-K042-10mg| Gentaur Distribution US, UK & Europe

CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.

Source: Human CTLA-4 Protein is expressed from human 293 cells (HEK293) . It contains AA Ala 37 - Phe 162 (Accession # Q6GR94-1) .

Molecule: CTLA-4.

Format: Powder.

Species: Human.

Application: This product is intended for immunocapture, biopanning and flow cytometry. This is a non-sterile product.

Kit Component: Antibody Purification: 1. Resuspend the lyophilized beads by adding the buffer of choice. 2. Add analyte to the suspension, mix and incubate to enable specific binding of the beads and the target protein. 3. Magnetize beads, remove supernatant, and wash unbound protein fractions to capture target protein-bound beads. 4. Wash, magnetize the beads and collect purified target protein for use in downstream applications.

Stability: Upon receipt, please store the beads at -20°C for 1 year in lyophilized state. Please avoid more than 3 freeze-thaw cycles. Immediate use after reconstitution is highly recommended.

Storage Conditions: -20℃, aviod light.

Shipping Conditions: RT