DNA Polymerase γ (POLG), His-FLAG-tag | 21001

DNA Polymerase γ (POLG), His-FLAG-tag | 21001 | Gentaur US, UK & Europe Disrtribition

Category: Molecular and Cell Biology/Protein

Application: Useful for DNA synthesis and DNA repair, as an antigen for Western blotting, and for inhibitor screening.

Background: POLG is the catalytic subunit of the mitochondrial DNA polymerase. The catalytic subunit contains three enzymatic activities, a DNA polymerase activity, a 3'-5' exonuclease activity that proofreads misincorporated nucleotides, and a 5'-dRP lyase activity required for base excision repair. Mutations in the POLG gene are associated with several mitochondrial diseases, including Alpers' disease, ataxia-neuropathy disorders, and dominant and recessive forms of progressive external ophthalmoplegia.

Description: Human DNA polymerase γ (gamma), also known as Pol gamma and POLG (GenBank Accession No. NM_002693), a.a. 2-1239 (end), with N-terminal His-tag and N-terminal FLAG-tag, MW=141 kDa, expressed in a baculovirus infected Sf9 cell expression system.

Product Type: Protein

Shippement Condition: -80°C