DNA Polymerase β (POLB), His-tag | 21000-2

DNA Polymerase β (POLB), His-tag | 21000-2 | Gentaur US, UK & Europe Disrtribition

Category: Molecular Biology Tools/Protein

Application: Useful for DNA synthesis and DNA repair, as an antigen for Western blotting, and for inhibitor screening.

Background: DNA polymerase involved in base excision and repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. The protein is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage.

Description: Human DNA polymerase ? (beta), also known as Pol beta and POLB (GenBank Accession No. NM_002690), a.a. 2-335 (end), with N-terminal His-tag, MW=39 kDa, expressed in an E. coli cell expression system.

Product Type: Protein

Shippement Condition: -80°C