Claudin-18 Isoform 2 CHO Cell Line | 78533

Claudin-18 Isoform 2 CHO Cell Line | 78533 | Gentaur US, UK & Europe Disrtribition

Category: Cell Signaling/Cell Line

Application: Test antibodies against claudin 18.2 Screen inhibitors or neutralizing antibodies  against claudin 18.2

Background: Claudins are integral membrane proteins and components of tight junction strands which serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. The claudin-18 gene has two splice variants: claudin-18.1, which is found primarily in the lung, and claudin-18.2, which is expressed exclusively in the stomach. Claudin-18.2 is highly expressed in gastric and pancreatic adenocarcinoma, located in the outer cell membrane, and involved in tumor development and progression. In addition, it has exposed extracellular loops and is available for monoclonal antibody binding. These biological characteristics suggest that it is an ideal target for therapy and  have led to the further development of monoclonal antibodies against claudin 18.2, such as Zolbetuximab.

Description: Recombinant clonal CHO cell line stably expressing full length human claudin 18.2 (claudin18 isoform 2, CLDN18.2, gene accession number NM_001002026.3). The stable clonal cell line was selected for high levels of claudin 18.2 expression compared to the parental CHO-K1 cell line.

Product Type: Cell Line

Shippement Condition: -80°C