Claudin-18 Isoform 1 CHO Cell Line | 78361

Claudin-18 Isoform 1 CHO Cell Line | 78361 | Gentaur US, UK & Europe Disrtribition

Category: Cell Signaling/Cell Line

Application: • Test antibodies against claudin 18.1 • Screen inhibitors or neutralizing antibodies against claudin 18.1

Background: Claudins are integral membrane proteins and major components of tight junction strands which serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. The claudin-18 gene has two splice variants: claudin 18.1, which is found primarily in the lung, and claudin 18.2, which is expressed exclusively in the stomach. In claudin 18-deficient studies, claudin 18.1 was identified as a regulator of normal lung homeostasis as its deficiency promoted the proliferative state of malignant cells found in lung adenocarcinomas.¹ Therefore, claudin-18.1 may be a potential therapeutic target in cancer. ¹

Description: Recombinant clonal CHO cell line stably expressing full-length human claudin 18.1 (claudin 18 isoform 1, CLDN18, gene accession number NM_016369.4). The stable clonal cell line was selected for high levels of claudin 18.1 expression compared to the parental CHO-K1 cell line.

Product Type: Cell Line

Shippement Condition: -80°C