Description
Claudin-18 Isoform 2 CHO Cell Line-78533-L | 78533-L | Gentaur US, UK & Europe Disrtribition
Category: Cell Signaling/Cell Line
Application: Test antibodies against Claudin 18.2 and anti-Claudin 18.2 CAR T cells for immunotherapy research and drug discovery. Screen inhibitors or neutralizing antibodies against Claudin 18.2
Background: Claudins are integral membrane proteins and components of tight junction strands which serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. The claudin-18 gene has two splice variants: claudin-18.1, which is found primarily in the lung, and claudin-18.2, which is expressed exclusively in the stomach. Claudin-18.2 is highly expressed in gastric and pancreatic adenocarcinoma, located in the outer cell membrane, and involved in tumor development and progression. In addition, it has exposed extracellular loops and is available for monoclonal antibody binding. These biological characteristics suggest that it is an ideal target for therapy and have led to the further development of monoclonal antibodies against claudin 18.2, such as Zolbetuximab.
Description: Recombinant clonal CHO cell line stably expressing full length human claudin 18.2 (claudin 18 isoform 2, CLDN 18.2, gene accession number NM_001002026.3). The stable clonal cell line was selected for different levels of Claudin 18.2 expression (High, Medium, and Low) compared to the parental CHO-K1 cell line.
Product Type: Cell Line
Shippement Condition: -80°C
