Anti-SARS-CoV-2 Nucleocapsid Antibody, Human IgG1 (AS95) (MALS verified) | NUN-CH14-100mg

Anti-SARS-CoV-2 Nucleocapsid Antibody, Human IgG1 (AS95) (MALS verified) | NUN-CH14-100mg| Gentaur Distribution US, UK & Europe

Nucleocapsid (N) protein is the most abundant protein found in coronavirus. CoV N protein is a highly immunogenic phosphoprotein important for viral genome replication and modulation of cell signaling pathways. It was first identified by a research team while they were screening for ADP-ribosylated proteins during coronavirus (CoV) infection (Grunewald M. E., et al. 2017, Virology; 517: 62-68) . The array of diverse functional activities accommodated in N protein makes it more than a structural protein but also an interesting target in the development of antiviral therapeutics. Because of the conservation of N protein sequence and its strong immunogenicity, N protein of coronavirus is chosen as a diagnostic tool.

Source: AntiN/ASARSN/ACoVN/A2 Nucleocapsid Antibody, Human IgG1 is isolated from a SARSN/ACoVN/A2 infected patient and is recombinantly produced from CHO cells. This monoclonal antibody is purified by Protein A affinity chromatography. As verified by binding test with NN/ANTD (Cat.No. NUNN/AC5143) and NN/ACTD (Cat.No. NUNN/AC5145) protein, this antibody can only bind to NN/ANTD (AA Gly 44 N/A Glu 174) . ELISA test validated that this antibody can bind multiple N protein variants with similar affinity as compared to the wild type N protein (Cat.No. NUNN/AC5227) .

Molecule: Nucleocapsid protein.

Species: Human.

Tag: Human IgG1 | Human Kappa.

Conjugate: Unconjugated.

Purity: 95%.

Charactirization: PBS, pH7.4.

Storage Conditions: -70℃.

Shipping Conditions: Dry ice