Anti-SARS-CoV-2 Nucleocapsid Antibody, Chimeric mAb, Human IgG1 (AM223) (MALS verified) | NUN-CH15-100mg

Anti-SARS-CoV-2 Nucleocapsid Antibody, Chimeric mAb, Human IgG1 (AM223) (MALS verified) | NUN-CH15-100mg| Gentaur Distribution US, UK & Europe

Nucleocapsid (N) protein is the most abundant protein found in coronavirus. CoV N protein is a highly immunogenic phosphoprotein important for viral genome replication and modulation of cell signaling pathways. It was first identified by a research team while they were screening for ADP-ribosylated proteins during coronavirus (CoV) infection (Grunewald M. E., et al. 2017, Virology; 517: 62-68) . The array of diverse functional activities accommodated in N protein makes it more than a structural protein but also an interesting target in the development of antiviral therapeutics. Because of the conservation of N protein sequence and its strong immunogenicity, N protein of coronavirus is chosen as a diagnostic tool.

Source: AntiN/ASARSN/ACoVN/A2 Nucleocapsid Antibody, Chimeric mAb, Human IgG1 is a chimeric monoclonal antibody recombinantly expressed from CHO cells, which combines the variable region of a mouse monoclonal antibody with human IgG1 constant domain. The mouse monoclonal antibody was obtained from a mouse immunized with recombinant SARSN/ACoVN/A2 Nucleocapsid Protein. This chimeric antibody is purified by Protein A affinity chromatography. As verified by binding test with NN/ANTD (Cat. No. NUNN/AC5143) and NN/ACTD (Cat. No. NUNN/AC5145) protein, this antibody can only bind to NN/ACTD (AA Ser 255 N/A Pro 364) . ELISA test validated that this antibody can potently recognize the N protein variant with mutation located within CTD (Cat. No. NUNN/AC52H9) . It can also bind multiple N protein variants with similar affinity as compared to the wild type N protein (Cat. No. NUNN/AC5227) .

Molecule: Nucleocapsid protein.

Species: Mouse.

Tag: Human IgG1 | Human Kappa.

Conjugate: Unconjugated.

Purity: 95%.

Charactirization: PBS, pH7.4.

Storage Conditions: -70℃.

Shipping Conditions: Dry ice