A20 Antibody / TNFAIP3 | V8384SAF-100UG

A20 Antibody / TNFAIP3 | V8384SAF-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 1 mg/ml in 1X PBS; BSA free, sodium azide free

Format: Purified

Clone: TNFAIP3/2813

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: IHC-P

Buffer: N/A

Limitation: This A20 antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: A20 (also known as TNFAIP3) is a zinc finger protein and inhibits NF-kappa B activation as well as TNF-mediated apoptosis. The protein has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. A20 is as a tumor suppressor and has been shown to protect MCF-7 breast carcinoma cells from TNF-induced apoptosis. High A20 expression levels were observed in more aggressive breast tumors (ER-negative, progesterone receptor-negative and high histological grade). These findings strongly suggest that A20 is a key protein involved in tamoxifen resistance.

Immunogen: A portion of amino acids 241-356 from the human protein was used as the immunogen for the A20 antibody.

Storage: Store the A20 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).