A20 Antibody / TNFAIP3 | V8384-20UG

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SKU:
800-V8384-20UG
Size:
20 ug
€649.00
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Description

A20 Antibody / TNFAIP3 | V8384-20UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Format: Purified

Clone: TNFAIP3/2813

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: IHC-P

Buffer: N/A

Limitation: This A20 antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: A20 (also known as TNFAIP3) is a zinc finger protein and inhibits NF-kappa B activation as well as TNF-mediated apoptosis. The protein has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. A20 is as a tumor suppressor and has been shown to protect MCF-7 breast carcinoma cells from TNF-induced apoptosis. High A20 expression levels were observed in more aggressive breast tumors (ER-negative, progesterone receptor-negative and high histological grade). These findings strongly suggest that A20 is a key protein involved in tamoxifen resistance.

Immunogen: A portion of amino acids 241-356 from the human protein was used as the immunogen for the A20 antibody.

Storage: Store the A20 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).

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