TRAM2 Antibody | R31118

TRAM2 Antibody | R31118 | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human, Mouse, Rat

Application: WB

Buffer: N/A

Limitation: This TRAM2 antibody is available for research use only.

Purity: Antigen affinity

Description: Translocation-Associating Membrane Protein 2, also called KIAA0057, is a protein that in humans is encoded by the TRAM2 gene. It is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing of nascent secretory and membrane proteins at the endoplasmic reticulum(ER) membrane. By genomic sequence analysis, Onuchic et al.(1999) mapped the gene to chromosome 6p21.1-p12 near the PKHD1 gene. Upon activation, quiescent hepatic stellate cells proliferate, change morphologically into myofibroblasts, and increase their synthesis of extracellular matrix proteins. Stefanovic et al.(2004) demonstrated that both TRAM2 and collagen type I are upregulated in activated rat and human hepatic stellate cells.

Immunogen: An amino acid sequence from the C-terminus of mouse Translocation-Associating Membrane Protein 2 (RFIHSQLRHWREYWKEQ) was used as the immunogen for this TRAM2 antibody (100% rat homology).

Storage: After reconstitution, the TRAM2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.