Description
TBP Polyclonal Antibody | E-AB-40487 | Gentaur US, UK & Europe Disrtribition
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Application: WB
Research Area: Cancer, Epigenetics and Nuclear Signaling
Background: The TATA binding protein (TBP) is a transcription factor that binds specifically to a DNA sequence TATA box. This DNA sequence is found about 25-30 base pairs upstream of the transcription start site in some eukaryotic gene promoters. TBP, along with a variety of TBP-associated factors, make up the TFIID, a general transcription factor that in turn makes up part of the RNA polymerase II preinitiation complex. As one of the few proteins in the preinitation complex that binds DNA in a sequence-specific manner, it helps position RNA polymerase II over the transcription start site of the gene. However, it is estimated that only 10-20% of human promoters have TATA boxes. Therefore, TBP is probably not the only protein involved in positioning RNA polymerase II. This antibody detects human TBP (~40 kDa) and mouse/rat Tbp (~35 kDa).
Lead Time: Order now, ship in 3 day
Concentration: 1mg/mL
Storage: Store at -20℃. Avoid freeze / thaw cycles.
Immunogen: Synthetic peptide of Human TATA-box-binding protein
Buffer: PBS with 0.05% Proclin300, 50% glycerol, pH7.3.
Purification: Antigen Affinity Purification
Dilution: WB 1:4000-1:6000
Conjugation: N/A
Calculated Molecular Weight: 38 kDa
Observed Molecular Weight: 38 kDa
Clonality: Polyclonal