T-bet Antibody (TBX21) | R31106

T-bet Antibody (TBX21) | R31106 | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human, Mouse, Rat

Application: WB

Buffer: N/A

Limitation: This T-bet antibody is available for research use only.

Purity: Antigen affinity

Description: TBX21 (T-Box 21), also called T-bet (T-box expressed in T cells), is a protein that in humans is encoded by the TBX21 gene. This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. Zhang and Yang(2000) mapped the mouse Tbx21 gene to chromosome 11D in an area showing homology of synteny with human chromosome 17. Szabo et al.(2000) showed that expression correlates with IFNG expression in Th1 and natural killer(NK) cells. Ectopic expression of T-bet both transactivated the IFNG gene and induced endogenous IFNG production. Finotto et al.(2002) observed reduced expression of the T(H)1 transcription factor T-bet in T cells from airways of patients with asthma compared with that in T cells from airways of nonasthmatic patients, suggesting that loss might be associated with asthma.

Immunogen: An amino acid sequence from the C-terminus of human T-box expressed in T cells (DKEAEGQFYNYFPN) was used as the immunogen for this T-bet antibody.

Storage: After reconstitution, the T-bet antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.