SHP-1 Antibody / PTPN6 | V8041-100UG

SHP-1 Antibody / PTPN6 | V8041-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Format: Purified

Clone: CPTC-PTPN6-2

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: WB

Buffer: N/A

Limitation: This PTPN6 antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: PTPN6, which is also designated as SHP-1, is expressed primarily in hematopoietic cells and characterized by the presence of two SH2 domains N-terminal to the PTP domain. It maps to 12p13, a region commonly involved in leukemia-associated chromosomal abnormalities. SHP-1 plays a role in modulating intracellular signaling for various molecules. In T-cell lymphomas and other malignancies, SHP-1 phosphatase expression is lost, by a thus far undetermined mechanism. Preliminary studies suggest that it may be helpful in differentiating mantle/marginal zone lymphomas (SHP-1+) from follicular lymphomas (SHP-1 negative).

Immunogen: Recombinant human full-length PTPN6 protein was used as the immunogen for the PTPN6 antibody.

Storage: Store the PTPN6 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).