Description
SHP-1 Antibody / PTPN6 | F54777-0.08ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human
Application: IF, IHC-P, WB
Buffer: N/A
Limitation: This SHP-1 antibody is available for research use only.
Purity: Purified
Description: PTPN6 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling.
Immunogen: A portion of amino acids 247-277 from the human protein was used as the immunogen for the SHP-1 antibody.
Storage: Aliquot the SHP-1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
