RPTPγ (PTPRG), GST-tag | 30047

RPTPγ (PTPRG), GST-tag | 30047 | Gentaur US, UK & Europe Disrtribition

Category: Protein Phosphatase/Receptor

Application: Useful for the study of enzyme kinetics and regulation, to dephosphorylate target substrates and for screening inhibitors.

Background: PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene.

Description: Protein tyrosine phosphatase PTPRG, also known as PTPγ (gamma) (GenBank accession No. NM_002841), a.a. 801-1147 (catalytic domain) with N-terminal GST-tag, MW=65.6 kDa, expressed in an E. coli expression system.

Product Type: Protein

Shippement Condition: -80°C