Recombinant Vaccinia virus Soluble Interferon α/β Receptor B18 Protein (His Tag) | PKSQ050089

Recombinant Vaccinia virus Soluble Interferon α/β Receptor B18 Protein (His Tag) | PKSQ050089 | Gentaur US, UK & Europe Disrtribition

Synonyms: Soluble interferon alpha/beta receptor B18; VACWR200

Active Protein: N/A

Activity: Recombinant Vacciniavirus Soluble Interferon α / β receptor B18 is produced by our Mammalian expression system and the target gene encoding His20-Glu351 is expressed with a 6His tag at the C-terminus.

Protein Construction: Recombinant Vacciniavirus Soluble Interferon α / β receptor B18 is produced by our Mammalian expression system and the target gene encoding His20-Glu351 is expressed with a 6His tag at the C-terminus.

Fusion Tag: C-His

Species: Vaccinia virus

Expressed Host: Human Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per μg as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 39.2 kDa

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Reconstitution: Please refer to the printed manual for detailed information.

Background: B18R, also known as B19R in the Copenhagen strain of Vaccinia, is a type I interferon (IFN)-binding protein encoded by the B18R open reading frame in the Western Reserve strain of vaccinia virus. B18R exists in two forms, soluble and membrane-bound form and also has a broad species specificity. B18R has high affinity for human IFN-alpha and also binds rabbit, bovine, rat, pig, and mouse IFN-alpha and IFN-beta. Secreted B18R binds to uninfected and infected cells. B18R presents at the cell surface and protects cells from the antiviral state. It has shown that binding of soluble recombinant B18R protects cultured cells from IFN and allows vaccinia virus replication.

Research Area: N/A