Recombinant Rhesus Macaque SLAM Family Member 7/SLAMF7/CD319/CRACC (C-6His) | PKSQ050108

Recombinant Rhesus Macaque SLAM Family Member 7/SLAMF7/CD319/CRACC (C-6His) | PKSQ050108 | Gentaur US, UK & Europe Disrtribition

Synonyms: SLAM Family Member 7; CD2 Subset 1; CD2-Like Receptor-Activating Cytotoxic Cells; CRACC; Membrane Protein FOAP-12; Novel Ly9; Protein 19A; CD319; SLAMF7; CS1

Active Protein: N/A

Activity: Recombinant Rhesus Macaque SLAM Family Member 7 is produced by our Mammalian expression system and the target gene encoding Ser23-Met226 is expressed with a 6His tag at the C-terminus.

Protein Construction: Recombinant Rhesus Macaque SLAM Family Member 7 is produced by our Mammalian expression system and the target gene encoding Ser23-Met226 is expressed with a 6His tag at the C-terminus.

Fusion Tag: C-6His

Species: Rhesus Macaque

Expressed Host: Human Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 23.3 kDa

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Reconstitution: Please refer to the printed manual for detailed information.

Background: SLAMF7 is a single-pass type I membrane protein and contains 1 Ig-like C2-type (immunoglobulin-like) domain. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruite signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. SLAMF7 positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, SLAMF7 can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.

Research Area: N/A