Recombinant Mouse Pleiotrophin/PTN/HB-GAM Protein (Active) | PKSM040395

Recombinant Mouse Pleiotrophin/PTN/HB-GAM Protein (Active) | PKSM040395 | Gentaur US, UK & Europe Disrtribition

Synonyms: Pleiotrophin; PTN; Heparin-binding brain mitogen; HBBM; Heparin-binding growth factor 8; HBGF-8; Osteoblast-specific factor 1; OSF-1;HARP;HB-GAM;HBBN;HBNF;OSF;Osf-1;Osf1

Active Protein: Active protein

Activity: A DNA sequence encoding the mouse PTN (P63089) (Met1-Asp168) was expressed.

Protein Construction: A DNA sequence encoding the mouse PTN (P63089) (Met1-Asp168) was expressed.

Fusion Tag: N/A

Species: Mouse

Expressed Host: Baculovirus-Insect Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 15.3 kDa

Formulation: Lyophilized from sterile 20 mM Tris, 1M NaCl, pH 7.4

Reconstitution: Please refer to the printed manual for detailed information.

Background: HB-GAM belongs to the pleiotrophin family. During embryonic and early postnatal development, HB-GAM is expressed in the central and peripheral nervous system and also in several non-neural tissues, notably lung, kidney, gut and bone. While in the adult central nervous system, it is expressed in an activity-dependent manner in the hippocampus where it can suppress long term potentiation induction. HB-GAM has a low expression in other areas of the adult brain, but it can be induced by ischemic insults, or targeted neuronal damaged in the entorhinal cortex or in the substantia nigra pars compacta. It is structurally related to midkine and retinoic acid induced heparin-binding protein and has a high affinity for heparin. HB-GAM binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. It also functions as a secreted growth factor and induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells.

Research Area: N/A