Recombinant Mouse Pentraxin-related protein PTX3(N-6His) | PKSM041439

Recombinant Mouse Pentraxin-related protein PTX3(N-6His) | PKSM041439 | Gentaur US, UK & Europe Disrtribition

Synonyms: alpha-induced protein 5; pentaxin-related gene, rapidly induced by IL-1 beta, tumor necrosis factor; Pentaxin-related protein PTX3; Pentraxin 3; pentraxin 3, long; pentraxin-3; pentraxin-related gene, rapidly induced by IL-1 beta; pentraxin-related protein PTX3; PTX3; TNF alpha-induced protein 5; TNFAIP5; TSG14; TSG-14

Active Protein: N/A

Activity: Recombinant Mouse Pentraxin-related protein PTX3 is produced by our Mammalian expression system and the target gene encoding His18-Ser381 is expressed with a 6His tag at the N-terminus.

Protein Construction: Recombinant Mouse Pentraxin-related protein PTX3 is produced by our Mammalian expression system and the target gene encoding His18-Ser381 is expressed with a 6His tag at the N-terminus.

Fusion Tag: N-6His

Species: Mouse

Expressed Host: Human Cells

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 90 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 41 kDa

Formulation: Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

Reconstitution: Not Applicable

Background: Pentraxin-related protein PTX3, also known as Tumor necrosis factor-inducible gene 14 protein (TSG-14), belongs to the pentraxin family. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. It’s subunit is a disulfide-linked homooctamer that binds to C1q. PTX3 concentration is elevated in the joint fluid of patients with rheumatoid arthritis (RA), indicating that PTX3 may be a potential mediator of immune response. PTX3 may also function in the regulation of the uptake and clearance of apoptotic cells by dendritic cells. An in vivo study showed that PTX3 transgenic mice are more resistant to sepsis and endotoxemia compared to wild-type during inflammatory injury.

Research Area: N/A