Recombinant Mouse IL-11RA (C-6His) | PKSM041427

Recombinant Mouse IL-11RA (C-6His) | PKSM041427 | Gentaur US, UK & Europe Disrtribition

Synonyms: IL-11 R alpha; IL11R alpha; IL11RA; IL-11Ra; Il11ra2; NR1

Active Protein: N/A

Activity: Recombinant Mouse Interleukin-11 Receptor Subunit Alpha-1 is produced by our Mammalian expression system and the target gene encoding Ser24-Gln367 is expressed with a 6His tag at the C-terminus.

Protein Construction: Recombinant Mouse Interleukin-11 Receptor Subunit Alpha-1 is produced by our Mammalian expression system and the target gene encoding Ser24-Gln367 is expressed with a 6His tag at the C-terminus.

Fusion Tag: C-6His

Species: Mouse

Expressed Host: Human Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 38.5 kDa

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Reconstitution: Please refer to the printed manual for detailed information.

Background: Interleukin 11 receptor alpha (IL 11 R alpha, IL 11 R alpha 1) originally designated NR1 in mouse, is a 49 kDa type I transmembrane protein that is a member of the gp130 subfamily of the hematopoietic cytokine receptor family. IL-11 R alpha first binds IL 11 with low affinity, then forms a high affinity receptor when complexed with gp130 homodimers. IL 11 R alpha is also anti-apoptotic for colonic epithelia, and increased IL 11 signaling may be a factor in inflammation-associated gastrointestinal cancer development. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth.A soluble form (sIL11RA) can act as an antagonist of IL11-dependent cell differentiation in cells where both transmembrane IL11RA and IL6ST are present.

Research Area: N/A