Recombinant JNK Monoclonal Antibody | E-AB-81448

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SKU:
575-E-AB-81448
Size:
100 μL
€946.00
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Description

Recombinant JNK Monoclonal Antibody | E-AB-81448 | Gentaur US, UK & Europe Disrtribition

Reactivity: Human, Mouse, Rat, Hamster

Host: Rabbit

Isotype: IgG

Application: WB

Research Area: Cancer, Immunology, Signal Transduction

Background: MAPK8(Mitogen-activated protein kinase 8) is also named as JNK1, PRKM8, SAPK1, SAPK1C and belongs to the MAP kinase subfamily. MAPK8 is activated by dual phosphorylation at a Thr-Pro-Tyr motif during response to UV light. MAPK8 functions to phosphorylate c-Jun at N-terminal serine regulatory sites of Ser-63 and Ser-73, mapping within the transactivation domain. Phosphorylation of these sites in response to UV results in transcriptional activation of c-Jun. It has 4 isoforms produced by alternative splicing with the molecular weight of 46 kDa and 48 kDa. This protein can be phosphorylated and this antibody recognizes the 46 kDa and 55 kDa bands in western blot.

Lead Time: 7~10 days

Concentration: 300 μg/mL

Storage: Store at -20℃. Avoid freeze / thaw cycles.

Immunogen: N/A

Buffer: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Purification: Affinity Purified

Dilution: WB 1:500-1:1000

Conjugation: Unconjugated

Calculated Molecular Weight: 48/53 kDa

Observed Molecular Weight: 46/54kDa

Clonality: Rabbit Monoclonal

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