Recombinant Human SMAD1 Protein (GST Tag) | PKSH033065

Recombinant Human SMAD1 Protein (GST Tag) | PKSH033065 | Gentaur US, UK & Europe Disrtribition

Synonyms: Mothers Against Decapentaplegic Homolog 1; MAD Homolog 1; Mothers Against DPP Homolog 1; JV4-1; Mad-Related Protein 1; SMAD Family Member 1;Transforming Growth Factor-Beta-Signaling Protein 1; BSP-1; SMAD1; BSP1; MADH1;SMAD 1;Smad1;hSMAD1;MADR1

Active Protein: N/A

Activity: Recombinant Human Mothers Against Decapentaplegic Homolog 1 is produced by our E.coli expression system and the target gene encoding Met1-Ser465 is expressed with a GST tag at the N-terminus.

Protein Construction: Recombinant Human Mothers Against Decapentaplegic Homolog 1 is produced by our E.coli expression system and the target gene encoding Met1-Ser465 is expressed with a GST tag at the N-terminus.

Fusion Tag: N-GST

Species: Human

Expressed Host: E.coli

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 78.7 kDa

Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0 .

Reconstitution: Please refer to the printed manual for detailed information.

Background: SMAD Family Member 1 (SMAD1) is a member of the dwarfin/SMAD family. SMAD1 has the highest expression in the heart and skeletal muscle, containing one MAD homology 1 domain and one MAD homology 2 domain, As a transcriptional modulator SMAD 1 is activated by bone morphogenetic proteins type 1 receptor kinase. Defects in SMAD1 may cause primary pulmonary hypertension (PPH1), characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure and death.

Research Area: Signal Transduction, Cancer, epigenetics and nuclear signal, metabolism, Stem cells