Recombinant Human S100A1 Protein (Active) | PKSH031792

Recombinant Human S100A1 Protein (Active) | PKSH031792 | Gentaur US, UK & Europe Disrtribition

Synonyms: S100;S100-alpha;S100A

Active Protein: Active protein

Activity: A DNA sequence encoding the human S100A1 (NP_006262.1) (Met 1-Ser 94) was expressed.

Protein Construction: A DNA sequence encoding the human S100A1 (NP_006262.1) (Met 1-Ser 94) was expressed.

Fusion Tag:

Species: Human

Expressed Host: E.coli

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 97 % as determined by reducing SDS-PAGE.

Endotoxin: Please contact us for more information.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 10.5 kDa

Formulation: Lyophilized from sterile PBS, pH 7.4

Reconstitution: Please refer to the printed manual for detailed information.

Background: S100A1 is a Ca2+binding protein of the EF-hand type that belongs to the S100 protein family. S100 proteins consisting of at least 19 members exist as dimers in the cytoplasm and/or nucleus of a wide range of cells; and are involved in the regulation of a number of cellular processes such as cell-cycle progression and cell differentiation.This protein has been shown to function in the processes including stimulation of Ca2+-induced Ca2+ release; inhibition of microtubule assembly; and inhibition of PKC-mediated phosphorylation.. Phosphoglucomutase is a target protein whose activity is antagonistically regulated by S100A1; and recently; S100A1 is also identified as a potent molecular chaperone and a new member of the Hsp70/Hsp90 multichaperone complex. S100A1 displays a tissue-specific expression pattern with highest levels in myocardium and is considered to be an important regulator of cardiac contractility. Accordingly; reduced expression or mutations of S100A1 gene have been implicated in cardiomyopathies.

Research Area: Signal Transduction, Tags & Cell Markers, Neuroscience,