Recombinant Human LAIR2/CD306 Protein (His Tag)(Active) | PKSH031383

Recombinant Human LAIR2/CD306 Protein (His Tag)(Active) | PKSH031383 | Gentaur US, UK & Europe Disrtribition

Synonyms: Leukocyte-Associated Immunoglobulin-Like Receptor 2; LAIR-2; CD306; LAIR2

Active Protein: Active protein

Activity: A DNA sequence encoding the human LAIR2 (NP_002279.2) (Met 1-Pro 152) with a C-terminal polyhistidine tag was expressed.

Protein Construction: A DNA sequence encoding the human LAIR2 (NP_002279.2) (Met 1-Pro 152) with a C-terminal polyhistidine tag was expressed.

Fusion Tag: C-His

Species: Human

Expressed Host: HEK293 Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 97 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 15.5 kDa

Formulation: Lyophilized from sterile PBS, pH 7.4

Reconstitution: Please refer to the printed manual for detailed information.

Background: Leukocyte-associated immunoglobulin-like receptor 2 ( LAIR2 ), also known as CD306, is a 131 amino acid protein containing one lg-like C2-type domain. It is expressed as a soluble receptor exhibiting high affinity for various collagen molecules to which it binds in a hydroxyproline-dependent manner. LAIR2 is a member of the immunoglobulin superfamily and was identified by its similarity to LAIR1, an inhibitory receptor present on mononuclear leukocytes. LAIR2 is thought to be secreted and may help modulate mucosal tolerance. As a natural competitor for LAIR1, soluble LAIR2 prevents binding of human LAIR1 to collagens and LAIR1 cross-linking, thereby regulating its inhibitory potential. Accordingly, LAIR2 is suggested to perform an immunoregulatory function.

Research Area: immunology