Recombinant Human KIM-1(C-6His) | PKSH033813

Recombinant Human KIM-1(C-6His) | PKSH033813 | Gentaur US, UK & Europe Disrtribition

Synonyms: HAVCR1, HAVCR, HAVCR-1, KIM-1, KIM1, TIM, TIM-1, TIM1, TIMD-1, TIMD1, Hepatitis A virus cellular receptor 1

Active Protein: N/A

Activity: Recombinant Human KIM-1 is produced by Mammalian expression system and the target gene encoding Ser21-Gly290 is expressed with a 6His tag at the C-terminus

Protein Construction: Recombinant Human KIM-1 is produced by Mammalian expression system and the target gene encoding Ser21-Gly290 is expressed with a 6His tag at the C-terminus

Fusion Tag: C-6His

Species: Human

Expressed Host: Human Cells

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.

Purity: >95% as determined by reducing SDS-PAGE

Endotoxin: Please contact us for more information.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 29.8kDa

Formulation: Supplied as a 0.2 μM filtered solution of PBS, pH7.4, 5% Trehalose

Reconstitution: Not Applicable

Background: Kidney injury molecule-1 (KIM-1) (also known as TIM-1 and HAVCR) is a type 1 transmembrane glycoprotein found on activated CD4+ T cells, especially Th2 cells, and dedifferentiated proximal tubule epithelial cells. In humans, KIM-1 levels are very low or undetectable in normal samples, but following drug toxicity or ischemic damage to the kidney, the 85 kD, mucin-rich extracellular region of this molecule is shed and detected at elevated levels in urine, serum, and plasma. Therefore, KIM-1 is a suitable renal biomarker capable of early detection and progressive monitoring of acute kidney injury beyond traditional injury markers such as serum creatinine (SCr) and blood urea nitrogen (BUN) which lack specificity and sensitivity. KIM-1 has also been implicated in the development of atopic airway disease (asthma) and Th2-biased autoimmune responses.

Research Area: N/A