Recombinant Human GPNMB Protein (aa 22-486, His Tag) | PKSH033371

Recombinant Human GPNMB Protein (aa 22-486, His Tag) | PKSH033371 | Gentaur US, UK & Europe Disrtribition

Synonyms: Transmembrane Glycoprotein NMB; Transmembrane Glycoprotein HGFIN; GPNMB; HGFIN;NMB;Osteoactivin

Active Protein: N/A

Activity: Recombinant Human Glycoprotein Non-Metastatic Melanoma Protein B is produced by our Mammalian expression system and the target gene encoding Ala22-Pro486 is expressed with a 6His tag at the C-terminus.

Protein Construction: Recombinant Human Glycoprotein Non-Metastatic Melanoma Protein B is produced by our Mammalian expression system and the target gene encoding Ala22-Pro486 is expressed with a 6His tag at the C-terminus.

Fusion Tag: C-6His

Species: Human

Expressed Host: Human Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 53.1 kDa

Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Reconstitution: Please refer to the printed manual for detailed information.

Background: Osteoactivin is an intracellular glycoprotein belongs to the NMB/pMEL-17 family; which is asscociated with cell endosomal/lysomal compartments. Human Osteoactivin is a 560 amino acid type I transmembrane protein; and one alternate splice form shows a 12 amino acid insert between amino acid 339-340. An additional 206 amino acid isoform shows a mutation at position 181 that results in a 26 amino acid substitution for the C-terminal 380 amino acids. Cells knowns to express Osteoactivin include fibroblast; osteoblasts; myeloid dendritic cell; melanocytes; plus fetal chondrocytes and stratum basale keratinocytes; macrophages/keratinocytes.

Research Area: N/A