Recombinant Human Follistatin/FST Protein (His Tag)(Active) | PKSH031488

Recombinant Human Follistatin/FST Protein (His Tag)(Active) | PKSH031488 | Gentaur US, UK & Europe Disrtribition

Synonyms: FS

Active Protein: Active protein

Activity: A DNA sequence encoding the human FST (NP_037541.1) (Met1-Asp329) was expressed with a polyhistidine tag at the C-terminus.

Protein Construction: A DNA sequence encoding the human FST (NP_037541.1) (Met1-Asp329) was expressed with a polyhistidine tag at the C-terminus.

Fusion Tag: C-His

Species: Human

Expressed Host: HEK293 Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 85 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per µg as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 34.4 kDa

Formulation: Lyophilized from sterile PBS, pH 7.4

Reconstitution: Please refer to the printed manual for detailed information.

Background: Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms; FST317 and FST344 containing 317 and 344 amino acids respectively; resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families; evidence was found for linkage between PCOS and follistatin. follistatin are expressed and subserve local regulatory roles in numerous extragonadal tissues; including brain; adrenal; bone marrow; and placenta but perhaps most notably in anterior pituitary-the classical target tissue for inhibin; the activin-follistatin system may play a key role in early embryogenesis. Follistatin binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone follistatin is a binding protein to activin. Since activin binds to follistatin; it is imperative to determine the nature of the activin/follistatin binding complex.

Research Area: Signal Transduction, epigenetics and nuclear signal,