Recombinant CDC42 Monoclonal Antibody | E-AB-81545

Recombinant CDC42 Monoclonal Antibody | E-AB-81545 | Gentaur US, UK & Europe Disrtribition

Reactivity: Human, Rat

Host: Rabbit

Isotype: IgG

Application: WB

Research Area: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Signal Transduction

Background: The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants.

Lead Time: 7~10 days

Concentration: 300 μg/mL

Storage: Store at -20℃. Avoid freeze / thaw cycles.

Immunogen: N/A

Buffer: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Purification: Affinity Purified

Dilution: WB 1:1000-1:2000

Conjugation: Unconjugated

Calculated Molecular Weight: 21kDa

Observed Molecular Weight: 21kDa

Clonality: Rabbit Monoclonal