PSMA Lentivirus | 78726

PSMA Lentivirus | 78726 | Gentaur US, UK & Europe Disrtribition

Category: Immunotherapy/Lentivirus

Application: Generate stable cell line expressing human PSMA with puromycin selection

Background: PSMA (prostate-specific membrane antigen, also known as Folate hydrolase 1, FOLH1), is highly expressed in prostate cancer cells and is used as a diagnostic and prognostic indicator of prostate cancer. The enzyme has folate hydrolase and peptidase activity. It plays a role in prostate cancer progression through the PI3K-Akt and MAPK-ERK1/2 pathways. PSMA/FOLH1is used in the clinic as a target for PET (positron emission tomography) imaging of prostate cancer whereas radioactive analogs are used for the treatment of prostate cancer. It is also expressed in other tumor types and in a few normal tissues. PSMA/FOLH1 is the target of CAR-T cells and bi-specific antibodies currently under development.

Description: The PSMA Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to transduce nearly all types of mammalian cells, including primary and non-dividing cells. The particles contain a human PSMA (NM_ 004476.3) driven by a CMV promoter and a puromycin selection marker (Figure 1).

Figure 1: Schematic of the lenti-vector used to generate the PSMA Lentivirus.

Product Type: Lentivirus

Shippement Condition: -80°C