Prostate-Specific Membrane Antigen Antibody (PSMA) | F43183-0.08ML

Prostate-Specific Membrane Antigen Antibody (PSMA) | F43183-0.08ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human

Application: IF, WB, IHC, ELISA

Buffer: N/A

Limitation: This PSMA antibody is available for research use only.

Purity: Antigen affinity

Description: GCPII is a zinc metalloenzyme that resides in membranes. Most of the enzyme resides in the extracellular space. GCPII is a class II membrane glycoprotein. It catalyzes the hydrolysis of N-acetylaspartylglutamate (NAAG) to glutamate and N-acetylaspartate (NAA). Neuroscientists primarily use the term NAALADase in their studies, while those studying folate metabolism use folate hydrolase, and those studying prostate cancer or oncology, PSMA. All of which refer to the same protein, glutamate carboxypeptidase II. PSMA is strongly expressed in the human prostate, being a hundredfold greater than the expression in most other tissues. In cancer, it is upregulated in expression and has been called the second-most-upregulated gene in prostate cancer, with increase of 8- to 12-fold over the noncancerous prostate. In human prostate cancer, the higher expressing tumors are associated with quicker time to progression and a greater percentage of patients suffering relapse. [Wiki]

Immunogen: A portion of amino acids 161-190 from the human protein was used as the immunogen for this PSMA antibody.

Storage: Aliquot the PSMA antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.