Programmed death ligand 1 Antibody / Pd-l1 / B7-h1 / Cd274 | RQ6346

Programmed death ligand 1 Antibody / Pd-l1 / B7-h1 / Cd274 | RQ6346 | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Mouse

Application: WB, Direct ELISA

Buffer: Lyophilized from 1X PBS with 2% Trehalose

Limitation: This Programmed death ligand 1 antibody is available for research use only.

Purity: Antigen affinity purified

Description: Programmed death-ligand 1 (PD-L1), also known as CD274 or B7-H1, is a protein that in humans is encoded by the CD274 gene. It is mapped to 9p24.1. PD-L1 is a 40kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis. It has been concluded that upregulation of PD-L1 on tumor MDCs downregulates T-cell immunity and that PD-L1 blockade may represent an approach for cancer immunotherapy. Additionally, PD-L1 can provide positive costimulatory signals for innate and adaptive immunity and for protection against intracellular bacterial infection. What�s more, it has been found that PD1/PDL1 pathway may be a good target for restoring antitumor immunity in ovarian cancer.

Immunogen: Recombinant mouse protein (amino acids E45-H239) was used as the immunogen for the Programmed death ligand 1 antibody.

Storage: After reconstitution, the Programmed death ligand 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.