PRMT1, GST-tag (E. coli-derived) | 51040

PRMT1, GST-tag (E. coli-derived) | 51040 | Gentaur US, UK & Europe Disrtribition

Category: Methyltransferase/Enzymes

Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling

Background: PRMT1 is a protein arginine methyltransferase that functions as a histone methyltransferase specific for histone H4. PRMT1 specifically methylates arginine-3 of histone H4 in vitro and in vivo. Methylation of arg3 by PRMT1 facilitates subsequent acetylation of histone H4 tails by p300. PRMT1 performs methylation of arg31 of STAT1 and this is required for transcription induced by IFN-alpha/IFN-beta. Arginine methylation of STAT1 is an additional posttranslational modification regulating transcription factor function, and alteration of arginine methylation might be responsible for the lack of interferon responsiveness observed in many malignancies. Type I PRMTs ((CARM1, PRMT1, PRMT2, PRMT3, PRMT6, and PRMT8) catalyze asymmetric dimethylarginine (ADMA), while type II PRMTs (e.g. PRMTs 5 and 7) catalyze SDMA. PRMT1 is the primary methyltransferase that deposits the ADMA mark, and it accounts for over 90% of this type of methylation.

Description: Human PRMT1 (GenBank Accession No. NM_001536), a.a. 2- end, with N-terminal GST-tag, MW= 68 kDa, expressed in an E. coli expression system.

Product Type: Protein

Shippement Condition: -80°C