Posaconazole | 27639-1

Posaconazole | 27639-1 | Gentaur US, UK & Europe Disrtribition

Category: Demethylase/Inhibitors / Activators

Application: N/A

Background: Posaconazole, also known as SCH 56592 or Noxafil, is a novel triazole antifungal compound that potently inhibits 14α-demethylation in a variety of fungi. Posaconzole, an itraconzole derivative with fluorine replacing chlorine in the phenyl ring and hydroxylation in the side chain, binds to the heme cofactor on the active site of 14α-demethylase, which converts lanosterol to 14α-dimethy lanosterol, resulting in the disruption of the integrity and function of the fungal cell membrane and inhibition of fungal growth.

Description: A sterol C14? demethylase inhibitor with an IC50 of 0.25 nM. Anti-fungal used to prevent serious fungal infections in people with a weakened ability to fight infection and to treat yeast infections.

Product Type: Inhibitor

Shippement Condition: Room temp. (continental US) or gel packs