Description
PKLR Var2 (PKL), His-tag | 40501 | Gentaur US, UK & Europe Disrtribition
Category: Metabolic Enzymes/Protein
Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Background: PKLR is a pyruvate kinase which catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP. This reaction is the rate-limiting step of glycolysis. PKLR gene encodes the L- and R-type isoenzymes through alternate splicing events controlled by different promoters. L-type isoform can also appear as a tetramer and is upregulated by glucose with implications in maturity-onset diabetes of the young.
Description: Human pyruvate kinase variant 2 (PKL), GenBank Accession No. NM_181871, full length with N-terminal His-tag 2-543 (end), MW=59 kDa, expressed in an E. coli expression system.
Product Type: Protein
Shippement Condition: -80°C
