Description
Phospho-Raf1 Antibody / c-Raf (pS621) | RQ5031 | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: Antibody in PBS with 0.02% sodium azide and 50% glycerol
Format: Purified
Clone: IOF-18
Host Animal: Rabbit
Clonality: Rabbit Monoclonal
Species Reactivity: Human
Application: WB
Buffer: N/A
Limitation: This phospho-c-Raf antibody is available for research use only.
Purity: Affinity purified
Description: Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). [UniProt]
Immunogen: A synthetic peptide specific to human Raf1 (surrounding pS621) was used as the immunogen for the phospho-c-Raf antibody.
Storage: Store the phospho-c-Raf antibody at -20 °C.
