Phospho-Raf1 Antibody / c-Raf (pS43) | RQ5030

Phospho-Raf1 Antibody / c-Raf (pS43) | RQ5030 | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: Antibody in PBS with 0.02% sodium azide and 50% glycerol

Format: Purified

Clone: ICO-18

Host Animal: Rabbit

Clonality: Rabbit Monoclonal

Species Reactivity: Human

Application: WB

Buffer: N/A

Limitation: This phospho-Raf1 antibody is available for research use only.

Purity: Affinity purified

Description: Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). [UniProt]

Immunogen: A synthetic peptide specific to human Raf1 (surrounding pS43) was used as the immunogen for the phospho-Raf1 antibody.

Storage: Store the phospho-Raf1 antibody at -20 °C.