Phospho-IkB alpha (Ser32/S36) Polyclonal Antibody | E-AB-20911

Phospho-IkB alpha (Ser32/S36) Polyclonal Antibody | E-AB-20911 | Gentaur US, UK & Europe Disrtribition

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Isotype: IgG

Application: WB, IHC-p, IF, ELISA

Research Area: Cancer, Epigenetics and Nuclear Signaling, Immunology, Signal Transduction

Background: Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.

Lead Time: 7~10 days

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthesized peptide derived from human IκB-α around the phosphorylation site of Ser32/36

Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4

Purification: Affinity purification

Dilution: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:10000

Conjugation: Unconjugated

Calculated Molecular Weight: 36 kDa

Observed Molecular Weight: 34 kDa

Clonality: Polyclonal