PD-1 CHO Cell Line | 78530

PD-1 CHO Cell Line | 78530 | Gentaur US, UK & Europe Disrtribition

Category: Cell Signaling/Cell Line

Application: • Screen and validate antibodies against PD-1 for drug discovery and research • Screen for compounds that regulate or inhibit PD-1 in a cellular context • Optimize and perform biological assays

Background: PD-1 (Programmed Death Protein 1, CD279) is a transmembrane protein expressed on the surface of immune cells that binds to PD-L1 or PD-L2, inducing apoptosis of T cells and inhibiting immune responses. Cancer cells often overexpress PD-L1 or PD-L2, allowing them to suppress T cell activation, evade the host immune response, and proliferate. Thus, disrupting the PD-1 co-inhibitory pathways may be an effective approach to developing anti-cancer therapies, as well as other immune diseases like multiple sclerosis, arthritis, lupus, and type I diabetes. The overexpression of PD-1 in this cell line allows for the study of PD-1 antibodies and other novel therapeutics.

Description: The PD-1 CHO cell line is a recombinant clonal stable CHO-K1 cell line constitutively expressing human PD-1 receptor (accession number: ­­­­­NM_005018). Surface expression of human PD-1 was confirmed by flow cytometry.

Product Type: Cell Line

Shippement Condition: -80°C